1.	為甚麼要保存寶寶的臍血？ 為寶寶及家人將來萬一需要治療惡性疾病時進行移植使用。
2.	為甚麼臍血保存的質量非常重要? 保存的臍血能否用於治療疾病取決於臍血保存的質量.
3.	由誰決定保存的臍血能否用於治療疾病? 病人的主治醫生.
4.	醫生根據甚麼決定保存的臍血能否用於治療疾病? 保存的臍血的有核細胞數量(幹細胞是有核細胞的一部份,但目前沒有好的方法進行幹細胞記數)。目前的細胞劑量是20 x 106有核細胞/每公斤體重.
5.	影響保存臍血的有核細胞數量最重要的因素是甚麼？ 任何臍血庫都不可能保存到比寶寶出生時所收集的還多的有核細胞數。 但是好的臍血庫能夠在細胞分離時防止幹細胞的丟失。 臍血庫通常情況下用有核細胞數量的回收率來作為衡量指標 (有核細胞回收率(%) = 提煉的有核細胞數/採集有核細胞數 X 100)。 臍血庫有核細胞 (幹細胞) 回收率差別是非常明顯的。另外，保存臍血中的紅細胞的濃度也是非常重要的因素。因為過多的紅細胞可以導致約30% 幹細胞在冷凍和復溫時死亡。因此，決定臍血保存質量的因素包括(1) 有核細胞提取率越高越好 (2) 混入有核細胞內的紅細胞越少越好。  更多 Quality of banking from different processing methods: With the table below, you can compare for yourself Progenics’ results Yang H et al. Cytotherapy  11: 18 (2009) abstract  (the full paper will be published in a scientific journal shortly) with results that have been published for other processing methods (Solves et al., Cytotherapy (2009) Vol. 11, 1101-1107). The most comprehensive study published recently was performed by Dr. Solves, a worldwide leading scientist in cord blood banking. This is the first study comparing the advantages and disadvantages of different methodologies used in routine cord blood banking.     PROCESSING METHOD       HES*** (n=92) Optipress*** (n=772) AXP*** (n=490) Progenics’ Double processing**** (n=3,219) Comments Before processing Volume of cord blood (mL) 108.2mL 109.2mL 104.8mL 74mL We process all samples (regardless of volume) with the client’s consent, so the volume is smaller. Total nucleated cells (TNC) x 106 1,237 1,469 1,406 1,087 Smaller volume, therefore, fewer cells. Hct** (%) 39.4 37.6 39.1 35.2 Hct is slightly lower since the red blood cells in smaller volumes of cord blood were diluted by the anticoagulant. After processing Volume 21.2 mL 40.8mL 21.0mL 22mL Standard volume after processing is <25mL. For larger volume samples, the Optipress II cannot limit the volume to less than 25mL. TNC X 106 (based on 74mL) 930.8 (637) 1,190 (806) 1,074 (758) 1,055 (1,055) The initial volume is much different but the number of cells after processing is nearly the same. TNC recovery* 76.4% 80.5% 60% (25 mL) 76.7% 97.6% There is approximately 20% difference in TNC recovery.   Hct 24.1% 36.6% 26.2% 7.7% Concentration of red blood cells is 3-4 times less after processing. Red blood cell depletion 86.1% 63.1% 86.8% 94.3% Depletion of many more red blood cells. Viability of cells 87.9% 93.8% 89.5% 94.8% More cells were alive (viable) after processing. TNC recovery rate 6.5% <60% 1.8% <60% 4% <60% 0.04% <80% At most banks at least 30-50% of samples have less than 80% recovery of TNC.  At Progenics, cord blood banking will be free if the TNC recovery rate is less than 80%. To our knowledge, ONLY Progenics has this guarantee. ***Published by Solves et al., Cytotherapy (2009) Vol. 11, No. 8, 1101-1107) **** Yang H et al. Cytotherapy  11: 18 (2009) abstract , (Yang H et al, Transfusion 2010 in press). Notes: *The recovery rate of TNC is the most reliable indicator for comparison (not CD34+ cells since“ the lack of a standardized method for CD34+ cell quantification makes it difficult to compare results among banks”) (Cytotherapy (2009) Vol. 11, No. 8, 1101-1107) . The best processing results are a higher recovery rate of TNC and a lower concentration of red blood cells (lower Hct). **Hct is an abbreviation for hematocrit (a blood test that measures the percentage of red blood cells found in cord blood either before or after processing).
6.	我甚麼時侯能知道寶寶臍血保存的質量? 由於臍血保存的溫度大約是零下190-196攝氏度(液氮氣態內)，如保存適當每年大約只有0.025% 細胞受宇宙射線導致死亡。所以長期低溫保存影響很小。因此，臍血保存的質量在臍血分離後就已確定。如問答5所述，臍血分離質量最重要的兩個因素就是(1) 有核細胞數量的回收率(%) (2) 保存的臍血中的紅細胞濃度(Hct%)。由於報告這兩項質量指標極具挑戰性， 因此，據我們所知目前只有寶濟臍血庫(Progenics)頒發此類證書。 更多>>

為什麼選擇寶濟臍血庫？